Biorevitalization is a non-volumizing injectable technique that does not reshape facial contours. Instead, it improves skin function and hydration biologically
This non-volumising method is ideal for clients seeking visible skin renewal with subtle, natural results. The procedure supports skin health from within, aligning with the regenerative goals of contemporary aesthetic practice.
What Is Biorevitalization?
Biorevitalization is a minimally invasive injectable treatment that uses biologically active compounds to restore hydration, tone, elasticity, and skin texture. It is not designed to add volume or change facial structure. Instead, it replenishes depleted components within the skin’s dermal layers.
This technique typically uses non-crosslinked hyaluronic acid, polynucleotides, peptides, vitamins, and amino acids to stimulate skin regeneration. These substances are introduced into the superficial to mid-dermis using fine-gauge needles.
Rather than producing instantly visible volume, revitalization initiates a biological response that improves skin quality over time. It is particularly suitable for clients who prefer progressive enhancement without dramatic change.
How Biorevitalization Works?
The treatment involves injecting active compounds into the superficial or mid-dermis. This layer is targeted because it houses fibroblasts, cells essential to maintaining dermal structure.
Dermal Delivery and Activation
Injectables are administered via microinjections across the treatment area. The biologically active substances penetrate the extracellular matrix and interact with resident cells. Hyaluronic acid, in particular, binds water molecules and boosts hydration at a cellular level.
Fibroblast Stimulation
Once injected, these compounds stimulate fibroblasts to increase collagen and elastin production. These structural proteins are critical to skin strength and resilience. In mature or environmentally damaged skin, fibroblast activity slows. Biorevitalization reactivates these cells, leading to improved dermal density and elasticity.
Enhanced Cellular Metabolism
Increased hydration improves microcirculation and nutrient exchange. This supports oxygenation, cellular repair, and the removal of metabolic waste. Together, these improvements help remodel the dermal matrix and reinforce skin structure.
Over time, the combination of collagen synthesis, improved hydration, and enhanced metabolism results in brighter, firmer, and more resilient skin.
Key Ingredients Used in Biorevitalization
Biorevitalization relies on high-quality compounds that deliver measurable skin benefits. These ingredients are selected for their ability to hydrate, stimulate cell activity, and promote regeneration.
Non-crosslinked hyaluronic acid
This is the foundational ingredient in most biorevitalization protocols. Unlike crosslinked HA used in fillers, non-crosslinked HA does not add volume. Instead, it restores hydration by binding water molecules within the dermis.
As hydration improves, skin appears smoother, firmer, and more elastic. The effect is particularly noticeable in dull, tired skin with early signs of ageing. This form of HA also facilitates better nutrient flow and cellular communication.
Polynucleotides (e.g. Nucleofill, Plinest)
Polynucleotides are DNA fragments purified for clinical use. These molecules stimulate fibroblast proliferation and improve skin tissue repair. They also act as antioxidants, helping to neutralise oxidative stress and reduce cellular damage.
Nucleofill and Plinest are commonly used to improve elasticity and texture, especially in delicate areas like the neck or periocular region.
Antioxidants, peptides, vitamins (e.g. mesotherapy blends)
Additional compounds such as peptides, amino acids, and vitamins are included in some formulations. These support collagen production, boost antioxidant defences and aid tissue repair.
Peptides help regulate skin cell behaviour, while antioxidants like vitamin C protect against environmental stress. Amino acids support protein synthesis, helping reinforce the dermal matrix. These blends often draw from mesotherapy principles but are tailored for regenerative aesthetic use.
Together, these ingredients promote a balanced environment within the skin and support long-term skin health.
Common Treatment Areas
Biorevitalization can be applied to various areas where the skin shows signs of dehydration, laxity, or dullness. The most frequently treated areas include:
- Face: To restore hydration, reduce fine lines, and improve skin tone
- Neck and décolleté: To improve elasticity and smooth crepey skin
- Hands: To enhance texture and firmness in ageing skin
- Periorbital region (under-eyes): To address dehydration and improve skin quality without volumisation
This technique is suitable for preventive use in younger clients and corrective applications in mature skin.
Benefits of Biorevitalization
Biorevitalization offers many clinical and cosmetic benefits without creating artificial volume. Key outcomes include:
- Improved skin hydration and elasticity
- Reduction in fine lines and improved smoothness
- Brighter, more even complexion
- Subtle, natural-looking enhancement
- Cumulative effects with repeated sessions
- Low risk of overcorrection or distortion
Because it acts biologically rather than structurally, the results appear natural and gradually improve with each session.
Biorevitalization vs Other Injectable Therapies
While biorevitalization shares some similarities with mesotherapy and filler treatments, its function and outcomes are distinct.
Biorevitalization is often used as part of a broader treatment plan. It complements procedures like microneedling, laser therapy, and botulinum toxin injections to support overall skin regeneration.
Treatment Protocols and Client Experience
A typical treatment plan includes three to four sessions spaced two to four weeks apart. Most clients begin to see visible changes after the first or second session, with optimal results becoming evident by the end of the treatment cycle.
Maintenance is recommended every four to six months, depending on the client’s skin condition and aesthetic goals.
What to Expect After Treatment
Minor redness, swelling, or pinpoint marks may occur immediately after the procedure. These effects usually resolve within 24 to 48 hours. Clients can typically return to daily activities the same day.
The full regenerative effect builds over time, supported by consistent hydration, collagen stimulation, and improved dermal function.
Ideal Candidates for Biorevitalization
Biorevitalization is suitable for a wide range of clients. It is particularly effective for those with:
- Dull or dehydrated skin
- Fine lines or early signs of ageing
- Reduced elasticity or uneven texture
- A desire for skin improvement without altering the facial volume
- A preference for low-downtime, regenerative treatments
Clients seeking natural enhancement and long-term skin health rather than immediate correction are excellent candidates for this protocol.
Biorevitalization Before and After
Results from revitalization are typically subtle but noticeable. After one or two sessions, the skin appears more hydrated, radiant, and firm. Over multiple sessions, fine lines soften, and skin tone evens out.
For visual comparisons, visit our educational hub to see biorevitalization before and after examples, practitioner case studies, and clinical observations.
Advancing Your Practice with Biorevitalization
As client demand shifts from volume correction to skin quality improvement, revitalization is essential to modern aesthetic protocols.
For medical aestheticians seeking to expand their regenerative treatment offerings, the Regenerative Medicine Masterclass provides in-depth training. This masterclass covers evidence-based techniques, safety protocols, and practical strategies for integrating biorevitalization into clinical practice.
Conclusion
Biorevitalization exemplifies the evolution of aesthetic medicine towards regenerative, client-centred care. By focusing on the skin’s biological function rather than external appearance alone, this treatment offers meaningful improvements in hydration, tone, and elasticity over time. Its non-volumising nature, minimal downtime, and cumulative effects make it an ideal option for clients seeking natural, gradual enhancement.
For aesthetic practitioners aiming to expand their expertise in evidence-based skin therapies, biorevitalization provides a powerful tool to support long-term skin health.
To gain in-depth clinical knowledge and master the application of regenerative injectables, explore the Regenerative Medicine Masterclass by HubMed Ed. This advanced course equips you with the latest protocols, safety guidance, and treatment strategies to elevate your aesthetic practice.
FAQs
What is biorevitalization treatment?
Biorevitalization treatment is a non-volumising injectable procedure that uses compounds such as hyaluronic acid and polynucleotides to restore skin hydration, elasticity, and tone. It revitalises the skin from within and is widely used on the face, neck, and décolleté.
How much does biorevitalization cost?
The cost of biorevitalization typically ranges from €150 to €350 per session, depending on the clinic, treatment area, and product used. To get accurate rates, search for “biorevitalization near me” or consult with a certified aesthetic provider in your region.
Is biorevitalization worth it?
Yes, biorevitalization is considered worthwhile for clients looking to improve skin quality naturally. It enhances hydration, firmness, and glow without altering facial structure. The results improve progressively with each session.
What is the difference between biorevitalization and fillers?
Biorevitalization injections work by regenerating the skin and stimulating collagen, while dermal fillers add volume and reshape contours. Biorevitalization is ideal for improving skin quality rather than structural augmentation.
How long does biorevitalization last on the face?
Biorevitalization facial results can last four to six months, depending on skin condition, lifestyle, and maintenance sessions. Clients who complete the full treatment protocol tend to experience longer-lasting benefits.
What are the side effects of biorevitalization?
Mild redness, swelling, or tiny injection marks may appear at the treatment site. These effects usually resolve within 24 to 48 hours. When performed correctly, biorevitalization is safe and well tolerated.
What not to do after biorevitalization?
After biorevitalization injections, avoid vigorous exercise, alcohol, direct sun exposure, and saunas for at least 24 hours. Clients should also avoid using exfoliants or retinol on the treated area for a few days.
Is biorevitalization FDA approved?
Some biorevitalization products are FDA approved, particularly those containing non-crosslinked hyaluronic acid. Approval may vary by brand and region. Clinics typically use CE-marked or FDA-cleared injectables depending on location.
What is the downtime for biorevitalization?
Downtime is minimal. Most clients resume daily activities immediately. Temporary redness or mild swelling may occur but typically subsides within one or two days.
References
- Sparavigna A, Tenconi B. Cutaneous Biorevitalization with Injective Treatments. Clinical, Cosmetic and Investigational Dermatology. 2019;12:681–688. doi:10.2147/CCID.S215186. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502127/. Accessed May 27, 2025.