Juvéderm for Vertical Lip Lines: Before-and-After Insights and Injection Tips

Vertical lip lines, often called smoker’s lines, can add years to one’s appearance and disrupt lip harmony. With increasing demand for non-surgical perioral rejuvenation, Juvéderm dermal fillers offer an advanced solution for smoothing lip wrinkles, with clinically proven techniques that improve texture, volume, and contour around the lips.

Understanding the Etiology of Vertical Lip Lines

Vertical lip lines are primarily caused by intrinsic aging and environmental stressors. Collagen loss and repetitive lip movements over time lead to fine lines forming above and around the mouth. Sun exposure, smoking, and genetics also play a significant role in how and when these lines emerge.

These perioral lines appear in both smokers and non-smokers, particularly in individuals over 40. Apart from aesthetics, they also affect function, causing lipstick to bleed, making the upper lip appear rigid, and creating a tired expression. Early intervention with soft fillers can address both appearance and structure.

Why Juvéderm Is an Optimal Choice for Vertical Lip Lines

Juvéderm fillers are renowned for their soft, malleable texture, which makes them ideal for treating delicate areas like the perioral zone. Specifically, Juvéderm Volbella XC is often preferred due to its low-viscosity formulation that integrates smoothly into superficial dermal layers, offering subtle yet effective correction.

Juvéderm’s HA-based formulas restore hydration and volume while respecting natural lip movement. Targeted Juvéderm courses at HubMed Ed offer practical guidance and expert insights for anyone aiming to refine their injection technique. It’s an excellent way to build confidence and precision in treating the perioral area.

Injection Protocols and Clinical Techniques

Precision is essential when addressing vertical lip lines with Juvéderm fillers. The following protocols and techniques offer guidance for optimal placement, product behavior, and natural results:

• Microdroplet injections: Ideal for fine perioral lines, microdroplets deliver small volumes of filler into the superficial dermis to minimize the risk of lumpiness and maximize smooth blending.
• Superficial threading: This technique involves gently threading filler just beneath the skin’s surface to soften etched-in lines and improve skin texture.
• Serial puncture technique: Involves placing multiple tiny injections directly into or adjacent to each line, enabling controlled filler distribution and precise targeting.
• Linear threading: A thin thread of filler is deposited as the needle or cannula is withdrawn along the length of the wrinkle. It’s useful for shallow to moderately deep lines.
• Fanning technique: Multiple linear threads are placed from a single-entry point in a fan-shaped pattern. This helps treat broader zones efficiently.
• Needle vs. cannula: Needles offer more control and precision in the perioral area, especially for superficial work. However, cannulas can be safer for minimizing vascular risks in select cases.
• Dosage control: Conservative amounts, typically 0.1 to 0.3 ml per side, are sufficient. 

Juvéderm Vertical Lip Lines Before and After: Clinical Observations

Before-and-after outcomes serve as valuable visual tools and clinical benchmarks when treating vertical lip lines:

• Line softening, not erasure: Patients should be counseled that Juvéderm smooths vertical lip lines but does not completely eliminate them. The result is a softened appearance and more supple upper lip texture.
• Natural movement retained: When treated conservatively, lips maintain their mobility and expressions without looking stiff or overdone.
• Immediate and progressive improvements: Mild volume restoration is visible immediately, while full results integrate over 7-14 days as the filler settles.
• Texture and hydration boost: Hyaluronic acid enhances dermal hydration, which also improves skin quality and line visibility over time.
• Duration of results: Most patients experience improvements lasting 6 to 12 months, depending on the product used (e.g., Volbella XC or Ultra XC) and metabolism.
• Patient satisfaction: Subtle but visible improvements lead to high satisfaction among patients seeking refined, understated rejuvenation.

Avoiding Adverse Outcomes in Lip Line Correction

Precision and restraint are key. Overfilling can result in upper lip stiffness, which impairs natural expression and looks artificial. Injecting too superficially increases the risk of the Tyndall effect, where filler appears bluish under the skin.

Additionally, asymmetry must be addressed during assessment. Respecting lip anatomy and function ensures smoother outcomes and higher patient satisfaction. Avoiding excessive correction maintains dynamic movement and a natural look.

Patient Demographics and Treatment Demand

Vertical lip line correction is one of the most sought-after enhancements in patients aged 40 and up. These patients typically desire conservative improvements that refresh their appearance without looking “done.”

Ideal candidates include individuals with fine to moderate static lip lines, good skin elasticity, and realistic expectations about results. Patients who are non-smokers or have quit smoking tend to have better outcomes, but even smokers can benefit when treatments are tailored with care. 

Product Selection Considerations

Choosing the right Juvéderm filler depends on the depth of the lines, lip mobility, and the patient’s desired outcome. Each product in the Juvéderm portfolio is tailored for specific tissue needs and aesthetic goals of the lips:

• Juvéderm Volbella: Best suited for fine, superficial perioral lines; offers smooth integration with minimal swelling.
• Juvéderm Ultra XC: Ideal for patients with more pronounced vertical folds needing additional support.
• Juvéderm Vollure XC: Can be considered when balanced flexibility and moderate structure are needed.
• Juvéderm Voluma XC (off-label): Occasionally used in perioral support zones for advanced aging when volume restoration is needed.

Combining Therapies for Enhanced Results

Combinatory approaches yield superior results in complex perioral aging. Neurotoxins such as Botox can be used to reduce muscle overactivity, allowing filler to settle and maintain shape longer. 

Skin boosters, polynucleotides, or biostimulators like Skinvive by Juvéderm can enhance dermal hydration and elasticity, improving filler integration and long-term skin health. Layering therapies over sessions ensures natural-looking rejuvenation.

Patient Education and Consent

Pre-treatment education builds trust and sets the foundation for satisfaction. Practitioners should explain that the goal is softening and not the total erasure of lines. Discuss potential side effects like bruising, swelling, or rare vascular issues.

Contraindications include hypersensitivity to hyaluronic acid, autoimmune disorders, and active skin infections. Ensure patients sign informed consent and understand aftercare guidelines to minimize risk.

Post-Injection Aftercare Protocols

Proper aftercare helps optimize results and minimize potential complications following vertical lip line treatment with Juvéderm. Educating patients on essential steps ensures a smoother recovery and better outcomes:

• Avoid pressure and lip movement: Do not press, pucker, or manipulate the lips for at least 24 hours.
• Refrain from smoking and makeup: Smoking and applying makeup can increase the risk of irritation or infection and should be avoided during the first 24 hours.
• Limit physical activity: Avoid strenuous exercise and alcohol consumption on the day of treatment.
• Use cold compresses sparingly: If swelling occurs, apply a cold pack gently without pressing the area.
• Sleep with head elevated: This can help reduce swelling overnight.
• Monitor for complications: Watch for signs like blanching, prolonged pain, or discoloration, which may indicate vascular compromise and require prompt medical attention.

Final Words

Juvéderm dermal fillers offer a refined, evidence-based solution for vertical lip lines, enabling natural-looking results with minimal downtime. When paired with precise injection techniques and patient education, outcomes can be both aesthetically pleasing and long-lasting. Continuous skill-building is key. Those looking to deepen their skills and stay current with best practices can explore in-depth courses and certification resources through the aesthetic medicine HubMedEd learning platform.

FAQs

What is the best lip filler for smokers lines?

Juvéderm Volbella XC is commonly regarded as the best filler for smoker’s lines due to its soft consistency and compatibility with superficial placement. It offers smooth integration for delicate perioral skin.

Where not to inject lip fillers?

Lip fillers should not be injected into major blood vessels, the wet-dry border (vermillion border) without precision, or too superficially, as this can lead to the Tyndall effect or nodules.

Is Botox or Juvéderm better for lip lines?

Botox and Juvéderm serve different purposes. Botox relaxes the muscle responsible for dynamic wrinkles, while Juvéderm fills static lines. They are often used together for optimal results.

How long does Juvéderm last for vertical lip lines?

Juvéderm fillers used for vertical lip lines can last between 6 to 12 months, depending on the product used, patient metabolism, and technique. Touch-ups may be needed for maintenance.

What is the best procedure for vertical lip lines?

A combination of treatments yields the best results. Juvéderm fillers soften static lines, Botox reduces dynamic movement, and skin boosters improve skin quality over time.

References:

1. Wisco L. Juvéderm: Hyaluronic Acid Dermal Filler. Healthline. Updated June 15, 2018. Accessed June 20, 2025. https://www.healthline.com/health/Juvéderm
2. Eccleston D, Murphy DK. Juvéderm^® Volbella^TM in the perioral area: a 12-month prospective, multicenter, open-label study. Clin Cosmet Investig Dermatol. 2012;5:167–172. doi:10.2147/CCID.S35800. https://pmc.ncbi.nlm.nih.gov/articles/PMC3496328/
3. Weiss R, Beer K, Cox SE, et al. A randomized, controlled, evaluator-blinded, multi-center study of hyaluronic acid filler effectiveness and safety in lip fullness augmentation. Dermatol Surg. 2021;47(4):527–532. doi:10.1097/DSS.0000000000002856. https://pmc.ncbi.nlm.nih.gov/articles/PMC8021234/‍
4. U.S. Food and Drug Administration. Dermal filler do’s and don’ts for wrinkles, lips and more. FDA. Published February 16, 2021. Accessed June 20, 2025. https://www.fda.gov/consumers/consumer-updates/dermal-filler-dos-and-donts-wrinkles-lips-and-more